Watford v Crystal Palace

Putting aside results against the ‘Big Six’, Watford have been excellent this season and have won nine of their last 13 unbeaten matches across all competitions. That includes each of their past four such games, while they’ve also done the double over Palace this term and can make it three on the spin versus the Eagles at Vicarage Road this weekend. Javi Gracia has a full complement to select from and after making eight changes to his side when they visited the Etihad last time out, so there should be no tired legs for the Hornets out there on the field. The likes of Roberto Pereyra, Troy Deeney and Gerard Deulofeu will return to the fold here, and can down a Palace side that have lost two of their last three outings. Roy Hodgson’s men were booed off the pitch in their most recent game hosting Brighton, while a run of three straight wins on the road has been somewhat deceptive as these came against League One Doncaster, a Leicester team in Claude Puel’s final game in charge and relegation-threatened Burnley.

Watford to win at 2.35*

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Wolves v Man Utd

Ole Gunnar Solskjaer’s winning run on the road came to an abrupt end at the Emirates, but he may have to accept extra-time here with Wolves showing their mettle against the ‘Big Six’ time and time again this season. The hosts are W3-D4-L3 in such fixtures across all competitions, picking up a point at Old Trafford earlier in the campaign, while they only failed to beat Chelsea last weekend courtesy of Eden Hazard’s stoppage-time equalizer. Nuno Espirito Santo has gotten his tactics spot on in these games as his side are tough to break down and can strike swiftly on the counter, and he has a full squad to choose from here which also helps his cause. United will probably progress to the semis and will be kicking themselves if they don’t with only their city neighbours still left in the tournament out of the ‘Big Six’, but Wolves can run them close and hand them a good scare along the way.

Draw at 3.25*

Millwall v Brighton

Millwall surprisingly beat Birmingham at the weekend but it’s hardly as though that one result papers over the cracks, with Neil Harris’ men still just one point above the relegation zone after Rotherham also earned victory at QPR. Having lost the previous four outings, the Lions can’t claim to be enjoying inspired form and the record of Championship sides hosting Premier League teams from the fifth round onwards is not great to say the least. Even excluding the top-flight’s ‘Big Six’, second-tier outfits are just W2-D3-L9 in such fixtures since 2009/10, and Millwall will have to battle a Brighton side that will have been buoyed by their win over Palace at Selhurst Park. Brighton have typically fared much better on home turf, but having gone W1-D5-L13 on the road between November 2017 and September 2018, they’ve won four of their 13 matches away from the Amex since then and can add another here.

Brighton to win at 2.10*

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 Odds are subject to change*